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L’Etat et le ministère de la Santé sont maintenant maîtres du jeu, je n’ai pas à porter de jugement sur ce qu’ils feront. Ces premiers résultats sont en cours de publication, mais il est utile de les commenter rapidement, car ils sont déjà fortement médiatisés ! Quant aux accusations de "fake news" ? C'est tout le problème de la chloroquine : "Les tests sur des patients humains [pour des infections virales autre que le paludisme, NDLR] ont, jusqu'à présent, toujours produits des résultats contrastés, difficiles à interpréter", rappelle Sarah D'Alessandro. D'abord, parce que "les données précises de cet essai clinique n'ont pas encore été publiées [dans une revue scientifique, NDLR] et n'ont donc pas encore pu être évaluées par des pairs", rappelle MedScape, un site à destination des professionnels de la santé. Il y a même eu 'fake news' pendant 36 heures inscrit sur le site du ministère de la Santé !". En Chine, 25 essais cliniques ont été menées ou sont en cours pour évaluer l'opportunité d'utiliser ce traitement pour les personnes contaminées. La chloroquine n'a pas été retenue, notamment, parce qu'elle se marie mal avec d'autres médicaments qui peuvent être nécessaires à certains patients atteints d'autres affections en plus du Covid-19, notamment certaines maladies auto-immunes.
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Des résultats préliminaires présentés par le professeur Didier Raoult portent sur un petit nombre de patients. Sibeth Ndiaye a également souligné l'importance de mener des essais à une plus grande échelle avant de conclure à l'efficacité de la chloroquine. Qu'est-ce dont que ce fameux remède ? De plus, l'IHU Méditerranée Infection de Marseille a une grande et longue expérience d'un dérivé de la chloroquine, mieux toléré, l'hydroxychloroquine. Six malades du groupe hydroxychloroquine ont aussi reçu en association un antibiotique, l'azithromycine. Certes, le dernier groupe ne comporte que six patients et "on ne peut encore considérer qu'une démonstration soit faite".
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Didier Raoult, le directeur de l'Institut hospitalo-universitaire (IHU) Mediterranee Infection de Marseille (Bouches-du-Rhone), a explique avoir mene un essai clinique durant lequel il avait traite 25 personnes contaminees par le coronavirus avec de la chloroquine. Apres six jours, il n'y avait plus que 25 % des patients ayant pris ce medicament qui avait toujours le virus dans le corps, soutient ce specialiste. En revanche, 90 % de ceux qui n'avaient pas pris de chloroquine continuaient a etre porteurs du Covid-19.

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Les effets secondaires sur le plan oculaire n’arrivent jamais avec des prescriptions d'environ dix jours comme celles auxquelles nous aurions affaire face au coronavirus : elles interviennent au bout de cinq ans, sur 1 % des patients. Ces spécialistes ont donc cherché à savoir quel pouvait être l'effet de l'hydroxychloroquine sur la charge virale de patients infectés par le SARS-CoV-2, dans le cadre d'une étude préliminaire ayant inclus 36 patients : 20 recevant de l'hydroxychloroquine et 16 un traitement de support des symptômes (groupe témoin). Les résultats sont donc encore plus spectaculaires quand on ajoute l'azithromycine à l'hydroxychloroquine". L'équipe du Pr Didier Raoult qui a mené une étude, que l'on pourrait qualifier de pilote, s'est appuyée sur le fait que la chloroquine exerce in vitro une inhibition de la croissance du SRAS-CoV-2 et sur les résultats d'un essai chinois ayant porté sur des malades infectés qui a montré des bénéfices à la fois cliniques et sur la clairance virale. C'est l'histoire d'un vieux médicament qui revient sur le devant de la scène. Des avantages qui expliquent pourquoi des recherches ont été menées pour tester son efficacité aussi bien contre le Zika, le Sras (Syndrome respiratoire aigu sévère) ou encore le Mers (coronavirus du syndrome respiratoire du Moyen-Orient). C’est bizarre : c’est moi le plus vieux, pourtant c’est moi le plus révolutionnaire ! Ceux qui n’ont pas reçu le Plaquenil sont encore porteurs à 90 % du virus au bout de six jours, tandis que ceux qui ont reçu le traitement sont 25 % à être positifs".
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