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Wieder brachte Wolzt beharrliches Fragen zur Ursache: Die Frau schluckte die Tabletten immer mit dem Essen, weil sie gehört hatte, dass das den Magen schone. Dies trifft zwar auf einige Medikamente zu, nicht aber auf Schilddrüsenhormone. "Die Nahrung im Darm verhinderte, dass die Hormone genügend aufgenommen wurden", sagt Wolzt. "Inhaltsstoffe im Essen oder in Getränken können die Wirkung von Medikamenten ziemlich verändern", sagt Klaus Mörike, Klinischer Pharmakologe am Uni-Klinikum in Tübingen. "Bei bestimmten Arzneimitteln muss man vorsichtig sein." Bisher fehlt ein wissenschaftlicher Überblick, wie häufig solche Wechselwirkungen vorkommen und welche Folgen sie für die Patienten haben. Mythos Schmerzmittel und Alkohol. Nach seiner Lungenentzündung hat der 70-Jährige keinen Appetit mehr. Er ernährt sich nur noch von Fruchtsaft, sechs Wochen später stirbt er überraschend. Seit Jahren nahm der Mann Warfarin ein. Es sollte verhindern, dass sich in seinem Körper ein Blutgerinnsel bildet und zu Herzinfarkt oder Schlaganfall führt - dann wurde es ihm selbst zum Verhängnis. "Vor allem mit Schlafmitteln, manchen Antidepressiva oder Opiat-Schmerzmitteln wird man müde und schläfrig", sagt Mörike. Bei anderen Schmerzmitteln gibt er Entwarnung: "Abgesehen von der Frage, ob einem Alkohol bei Schmerzen guttut, ist gegen ein Gläschen Wein nichts einzuwenden", sagt Mörike. "Nur keine harten Schnäpse - das kann die reizende Wirkung der Medikamente auf die Magenschleimhaut verstärken." Selbst bei Medikamenten, bei denen Wechselwirkungen gut bekannt sind, kommen Ärzte diesen oft nicht gleich auf die Spur. Einer 64-jährigen Frau etwa brachten die Verwandten nach der Herzklappen-Operation Multivitamintabletten mit, sie meinten es gut. Michael Wolzt, Kardiologe an der Uni-Klinik für Klinische Pharmakologie in Wien, wunderte sich indes, warum das blutgerinnungshemmende Marcumar nicht wirkte. Einnahme von Medikamenten: Am besten immer mit Leitungswasser.

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